Treatment and Prevention

Preparation Insular Active: instructions for use

Insular Active refers to human insulin. It is used in the treatment of diabetic pathology and impaired carbohydrate metabolic processes. It has a persistent hypoglycemic effect.

International non-proprietary name

Insulin human recombinant.

Insular Active refers to human insulin.

ATH

ATH code: A10A B01.

Forms of release and composition

In the form of an injection solution. The main active ingredient is recombinant human insulin 100 IU. Excipients: glycerin, water for injection, metacresol.

It is a clear liquid in cartridges of 3 ml or vials of 5 ml (in each package of 5 pieces).

pharmachologic effect

Medication is one of the common forms of human insulin. Characterized by a short action. The active substance rapidly interacts with the outer receptors of the cell membranes. In this case, a specific insulin-receptor complex is formed. With it, there is a stimulation of all processes occurring inside the cells. At the same time, separate enzymes are also synthesized.

The decrease in the amount of glucose in the blood is associated with the acceleration of its transport inside the cells, the best absorption of glucose by the cells of the tissue. The active complex stimulates glycogenogenesis, lipogenesis. When this occurs, a decrease in the synthesis of saccharides in the liver.

Pharmacokinetics

How quickly the drug is absorbed depends on the method, where and in what quantity the drug is injected. The distribution in tissues is uneven. Insulin is not able to penetrate into breast milk and through the protective barrier of the placenta, so pregnancy is not a contraindication to the use of the drug.

The destruction of the active complex occurs under the influence of insulinase in the liver and kidneys. Eliminated from the body by renal filtration within a few minutes.

Indications for use

Recommended for use with:

  • diabetes;
  • emergency conditions in people with diabetic pathology;
  • decompensation of carbohydrate metabolism.
The drug is prescribed for diabetes.
The drug is prescribed for emergency conditions in people with diabetic pathology.
The drug is prescribed for decompensation of carbohydrate metabolism.

Contraindications

There are a number of direct contraindications to the use of Insular Asset indicated in the instructions. Among them:

  • hypoglycemia;
  • hypersensitivity and insulin or other medication components.

The exception is desensitization therapy.

Carefully

With caution, the drug is prescribed to people with renal and hepatic failure, patients who have previously been treated with other types of insulin.

How to take Insular Active?

Subcutaneous injection is done. In some cases, it is recommended to inject intramuscularly. To avoid subcutaneous reactions, it is recommended to change the place for the injection. You need to be careful that the needle does not hit the blood vessel. Injection sites are never rubbed.

The drug is administered subcutaneously.

With diabetes

Medicinal substance must be taken half an hour before meals. The temperature index of the solution is not lower than room temperature.

Side Effects of Insular Asset

Against the background of long-term use, such negative reactions may occur:

  1. Hypoglycemia. This is one of the most common side effects of insulin therapy. In severe cases, it causes loss of consciousness or sugar coma. The frequency of this manifestation is individual, since depends on the insulin dose and lifestyle of the patient.
  2. Local allergy. It appears quite often in the form of hyperemia and itching. This symptom passes from 1 week to a month. Insulin does not always affect the appearance of this trait. This may be other external factors or little experience with injection.
  3. Systemic allergies It appears even less often. It leads to skin rashes all over the body, shortness of breath, wheezing, lowering blood pressure, increased sweating. Increased systemic allergy is life threatening.
  4. Lipodystrophy. It occurs extremely rarely at the injection site.
Against the background of long-term use, such negative reactions as shortness of breath may occur.
Against the background of long-term use, such negative reactions as lowering of blood pressure can occur.
On the background of long-term use, such negative reactions as increased sweating may occur.
Against the background of long-term use, such negative reactions as lipodystrophy may occur.
Against the background of long-term use, such negative reactions as hypoglycemia may occur.
Against the background of long-term use, negative reactions such as skin rashes can occur.

If any of these symptoms occur, you must adjust the dose or replace it with another insulin. In extremely severe cases, the medical preparation is canceled completely, symptomatic treatment is carried out and new insulin is prescribed.

Influence on ability to operate mechanisms

The development of hypoglycemia, as a possible side effect, affects the concentration of attention, which increases the risk of an accident in a situation of driving a car or other complex mechanisms.

The patient should be informed in advance about what to do before you get behind the wheel to avoid an attack of hypoglycemia. If such a condition occurs frequently, it is better not to drive a car.

special instructions

Improper treatment or skipping the injection provokes the development of a hyperglycemic state.

Do not mix different types of insulin in the same syringe. Only mixing this medication (in vials) with Insular Stabil is permissible. But such a mixture should be introduced immediately after preparation. Cartridges are not allowed to be used several times, they are disposable. Injections are always done with new sterile syringes.

Use in old age

Correction of insulin dosage in older people is not required.

Appointment to children

It is used in newborns when vital signs require it. But the dose should be constantly monitored and set in accordance with changes in the condition of the child.

Use during pregnancy and lactation

It is important to monitor blood glucose in women who are carrying a fetus and are being treated with insulin. At the beginning of gestation, it is required less, and at the end - more. Insulin need is sometimes reduced during delivery. But a few days after the baby is born, the glucose level should return to normal quite quickly.

There are no restrictions on the use of the drug when breastfeeding, because Therapy is safe for both mother and child.
In patients with chronic renal failure, mild dosage adjustment is not required.
The drug is used in newborns when it is required by vital signs.
There are no restrictions on the use of the drug in the gestational period, since Therapy is safe for both mother and child.
A dosage adjustment is required because the need for it in patients with liver pathologies is greatly increased.

There are no restrictions on the use of the drug in the gestational period and breastfeeding, because Therapy is safe for both mother and child. But in this case, a constant correction of the dosage of the drug is required to prevent the development of hypoglycemia.

Use in violation of kidney function

In patients with chronic renal failure, mild dosage adjustment is not required. Only when the patient’s condition deteriorates, the insulin dose is increased or reduced, taking into account clinical indications.

Use in violation of the liver

A dosage adjustment is required because the need for it in patients with liver pathologies is greatly increased.

Overdose of Insular Active

It is impossible to determine exactly what overdose is caused by Insular Asset, because hypoglycemia provokes a number of unfavorable factors: an excess of insulin in the blood, the ratio of glucose to the general metabolism, excessive exercise.

Symptomatic therapy. A mild grade is treated with glucose or sugar-containing foods. With moderate severity, glucagon is injected into a vein or muscle, after which food is offered that is high in fast carbohydrates. With sugar coma, glucagon is injected subcutaneously.

Interaction with other drugs

Many drugs in varying degrees, affect glucose metabolism. The need for insulin increases when it is used together with certain hyperglycemic agents, glucocorticoids, growth hormone and thyroid hormones, sympathomimetics, Salbutamol and thiazides.

A smaller amount of insulin is required if you take hypoglycemic and antidepressant drugs together, salicylates, OK, MAO inhibitors, Enalapril, certain beta-blockers.

Analogs

There are a number of substitutes for this drug, similar in constituents and therapeutic action. The most popular among them are:

  • Actrapid;
  • Vosulin-R;
  • Gensulin R;
  • Insuvit;
  • Insugen-P;
  • Insuman Rapid;
  • Rinsulin-R;
  • Humodar;
  • Humulin Regulyar.
How to prick insulin?

Compatibility with alcohol

The drug can not be combined with alcohol because of the risk of hypoglycemia.

Pharmacy vacation terms

A medical prescription is required for purchase at pharmacies.

Can I buy without a prescription?

Impossible.

Price for Insular Active

The cost is:

  • cartridges - 1420-1500 rubles. per package;
  • bottles - 1680-1830 rub. per pack.

The price depends on the region of sale and pharmacy mark-up.

Drug storage conditions

Storage space should be dry and dark, restricted from access by children, with a temperature regime of + 2 ... + 8 ° C. The preparation is not subject to freezing. After opening, another 28 days can be stored (t = + 25 ° C). Protect open packaging from light and do not heat it.

The place for storage of the preparation should be dry and darkened, limited from the access of children, with a temperature regime of + 2 ... + 8 ° C.

Shelf life

Not more than 2 years.

Manufacturer

The manufacturing company of Insular packaged in cartridges is Halychpharm, packaged in vials - Kievmedpreparat, Ukraine.

Reviews of Insulare Active

Makar, 47 years old, Sevastopol

For a long time I have diabetes. Previously, he took Vosulin, now he has disappeared from the sale, so they appointed injections of Insular Active. It works well, sugar is kept at about the same level. The only thing that upsets is the price.

Elena, 29 years old, Mariupol

On Insular Active, sugar returned to normal, attacks of hypoglycemia began to occur much less frequently. Although the drug is expensive, but effective, I advise.

Vladimir, 56 years old, Yekaterinburg

I am satisfied with this insulin. I use it in cartridges. It is convenient to enter, and 1 injection is enough for a day. I had no adverse reactions. Sugar is now held at the same level.

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