The most common cardiovascular disease is hypertension. For its treatment, several groups of drugs are used, which have different mechanisms of action for the treatment of high blood pressure. An important aspect affecting mortality from cardiovascular disease is an increase in blood pressure. The drug Vazotenz N. is used to regulate the level of pressure figures.
The drug Vazotenz N. is used to regulate the level of pressure figures.
International non-proprietary name
Losartan in combination with diuretic (hydrochlorothiazide).
Forms of release and composition
This drug is available in the form of tablets that are film coated. Tablets are available with the following dosages:
- 1 tablet contains 100 mg of losartan and 25 mg of hydrochlorothiazide, in 1 blister 10 tablets, 3 blisters per package.
- 1 tablet contains 50 mg of losartan and 12.5 mg of hydrochlorothiazide, in 1 blister, 10 tablets, 10 blisters in the package.
This drug is available in the form of tablets that are film coated.
The main mechanism of action is to block the receptors for angiotensin II, which is the main contractile substance in the body in relation to the vessels. Angiotensin, connecting with its receptors on the walls of blood vessels, causes their reduction throughout the body, which causes an increase in pressure. Synthesis of this substance occurs in the renal tissue from renin protein under the influence of angiotensin-converting enzyme.
Blocking angiotensin receptors does not cause vascular contraction, as a result of which pressure does not increase. The active ingredient of the drug interacts only with angiotensin 2 receptors, thereby not having any other effects on other receptors.
The main mechanism of action is to block the receptors for angiotensin II, which is the main contractile substance in the body in relation to the vessels.
The mechanism of action of hydrochlorothiazide: enhancing urine production, reducing pressure due to the removal of excess fluid from the body.
Losartan is rapidly absorbed from the intestines, from where it enters the liver and undergoes biotransformation. Only 33% of the accepted dose is not metabolized. With biotransformation, losartan is converted into an active metabolite. It is a hypotensive agent and is not inferior to losartan in terms of effectiveness.
The highest concentration of the active substance in the body is created 2 hours after ingestion. The effect of one pill lasts 24 hours. The accumulative hypotensive effect of the drug develops for a period of 1 to 3 weeks.
Indications for use
The main indications for admission are:
- Hypertonic disease.
- Arterial hypertension of various origins.
- Increased pressure in adolescents and young children.
- Supportive therapy for post-infarction conditions.
- Heart failure (as a substitute for substances from the group of angiotensin converting enzyme inhibitors).
This medicine has the following absolute contraindications:
- renal failure with creatinine clearance below 30 ml per minute;
- second and third trimester of pregnancy and the entire period of breastfeeding;
- acute and chronic liver failure;
- the patient has biliary cirrhosis, hepatocellular carcinoma.
If the patient has bilateral renal artery stenosis or renal artery stenosis with a missing second kidney, the medication is used only by evaluating the possible risks and the expected positive result.
How to take vazotenz n
Before starting treatment, it is necessary to conduct a comprehensive biochemical examination of the body. Important indicators for the adequate treatment of hypertension and the prevention of its complications are blood lipids. They include the concentration of cholesterol, triglycerides and low-density lipoproteins, since these substances are involved in the formation of atherosclerotic plaques.
The dose of the drug for adults - 1 tablet 1 time per day. If possible, you should resort to dose titration. With regular use of blood pressure decreases and stabilizes at 4 weeks of taking the drug.
In case of heart failure, the medicine must be applied once a day. Use the drug with caution. You can control the effect of the disappearance of cardiac asthma and edema in the legs. In case of insufficient effect of the drug, you can increase the intake of diuretics in the form of independent drugs.
The dose of the drug for adults - 1 tablet 1 time per day.
Patients who suffer from diabetes are prone to kidney disease. Such diseases are accompanied by impaired renal function. This should be taken into account when prescribing a drug, since it is excreted mainly by the kidneys, and the delay of the active substances in the body increases the toxic side effects of the drug.
Unwanted effects can manifest in different organs and systems.
When taking the drug often have abdominal pain, diarrhea, nausea, vomiting. Less common constipation and flatulence. It is also possible to increase liver enzymes in laboratory studies.
When taking the drug often have abdominal pain.
From the musculoskeletal system
Often there is pain in the back, pain in the legs. Muscle cramps occur less frequently.
central nervous system
Acceptance of losartan is often accompanied by dizziness and, less commonly, headache. In rare cases, paresthesia, tremor of the extremities, and migraine may occur. In very rare cases - short-term loss of consciousness.
On the part of the respiratory system
During treatment with a drug, cough, catarrhal symptoms of the upper respiratory tract, nasal sinuses and nasal congestion may occur.
Coughing may occur during drug treatment.
On the part of the skin
Possible manifestation of urticaria or pruritus. These phenomena are minor and pass after the end of the course of treatment. In severe cases, you can use drugs to alleviate side effects.
From the genitourinary system
Perhaps frequent urination associated with the action of hydrochlorothiazide.
Since the cardiovascular system
Long and uncontrolled use of the drug increases the risk of ischemic stroke and myocardial infarction in people with atherosclerosis.
Long and uncontrolled use of the drug increases the risk of ischemic stroke.
Before using this drug, it is necessary to test for individual sensitivity. In case of allergic reactions in the form of urticaria or pruritus, the use of this drug is prohibited.
Allergic reactions, such as angioedema or vasculitis, are possible during administration. These conditions are extremely rare, but one cannot exclude their development in the treatment with losartan.
Influence on ability to operate mechanisms
Losartan does not directly affect the state of the central nervous system, but dizziness often occurs in the number of side effects. Based on this, at the time of therapy it is necessary to refrain from using vehicles or mechanisms that require concentration of attention.
At the time of therapy should refrain from the use of vehicles.
Since the use of the drug can cause potassium retention in the body, co-use with potassium-containing products, potassium-sparing diuretics (which affect the aldosterone system and cause potassium retention in the body), as well as agents that can indirectly cause an increase in plasma potassium concentration, is undesirable due to the risk of developing hyperkalemia.
If you need to take a drug that affects the composition of blood electrolytes (especially potassium), you should regularly conduct tests for the content of potassium in the blood.
Use during pregnancy and lactation
This drug, like any other of the group of angiotensin II receptor inhibitors, is strictly contraindicated for use by pregnant women in the second and third trimester, as well as for the entire period of breastfeeding. If it is necessary to reduce high blood pressure during pregnancy, it is necessary to resort to the use of drugs from other therapeutic groups.
This drug is strictly contraindicated for use by pregnant women in the second and third trimester.
Purpose Vazotenza H children
Data on the safe use of the drug in persons under 18 years are not available. On this basis, it is not recommended to prescribe the drug to children, since it is impossible to predict its effect on the children's body.
Use in old age
The dosage of losartan in the elderly is no different from the dosage for adults. But older people often have problems with the kidneys and liver, which must be considered when prescribing the drug.
Use in violation of kidney function
In the case of serum creatinine concentration up to 500 μmol (this figure corresponds to stage 2 of chronic kidney disease), the dose of the drug can not be adjusted, because the residual kidney function is sufficient for the timely removal of the drug from the body.
The dosage of losartan in the elderly is no different from the dosage for adults.
If creatinine clearance is below 30 ml per minute, then the use of the drug is prohibited, since even hemodialysis has a dubious effect regarding the removal of the active substance from the body.
Use in violation of the liver
When liver failure can not prescribe the drug, since the metabolism of the active substance is highly dependent on the function of the liver.
In case of overdose, severe hypotension can occur, which can lead to shock, collapse and loss of consciousness. Symptomatic therapy is used to restore normal blood pressure. Hemodialysis is not effective for removing excess amount of the drug from the body.
Interaction with other drugs
For the treatment of hypertension, it is sometimes effective to use several drugs from different groups to achieve the necessary pressure figures. Most often, these substances are already together inside the tablets. The most successful combinations with this medicine include those that still include thiazide diuretics (the main representative of the group is hydrochlorothiazide) or calcium channel blockers (the main representative of the group with a long cumulative effect is amlodipine).
For the treatment of hypertension, it is sometimes effective to use several drugs from different groups to achieve the necessary pressure figures.
Use together with substances from the group of angiotensin-converting factor blockers, such as lisinopril, is not recommended, since the mechanism of action is to act on the same system, but on different links. This is called a double blockade of the renin-angiotensin system. This combination does not enhance the therapeutic effect, but increases the toxicity of drugs for the body.
Combined use with angiotensin-converting enzyme inhibitors may increase the concentration of lithium in the blood. High concentrations of lithium have a toxic effect on the body. It is necessary to avoid this combination of drugs.
When using nonsteroidal anti-inflammatory drugs (drugs that block cyclooxygenase 2) with this medication, a weakening of the hypotensive effect may develop. The joint use of these drugs causes a delay of potassium in the body, which threatens problems with the cardiovascular system.
Care must be taken when combining these drugs and in case of changes in laboratory parameters or deterioration of the patient's condition, the need to reduce dosages or discontinue one of the drugs should be considered.
Compatibility with alcohol
Since the drug is metabolized in the liver, alcohol should be avoided while taking the medicine. This will reduce the load on the liver and improve its function.
Since the drug is metabolized in the liver, alcohol should be avoided while taking the medicine.
On the market there is such an analogue as Loseta.
Differences of Vazotenz and Vazotenz N
Adding the letter H to the name of the drug says that in addition to the main active ingredient is hydrochlorothiazide, which is a diuretic. This should be taken into account when prescribing the drug, because the presence of hydrochlorothiazide adds an additional hypotensive effect and its own side effects.
Vacation conditions of Vazotena H from the pharmacy
Can I buy without a prescription
Like all drugs from the group of angiotensin II receptor blockers, it is dispensed from a pharmacy without a prescription.
Price for Vazotenz N
The price varies from 250 to 650 rubles.
Like all drugs from the group of angiotensin II receptor blockers, it is dispensed from a pharmacy without a prescription.
Drug storage conditions
The drug is stored in its original packaging at room temperature. Keep out of reach of children.
3 years from the date of manufacture indicated on the package.
Manufacturer Vazotena N
Reviews of Azotensin N
Sergey, 52, Cardiologist, Moscow
Angiotensin receptor inhibitors are indispensable drugs for the treatment of hypertension in adults. Often we use losartan as the main drug in patients who complain of cough after a long use of ACE inhibitors.
Oksana, 48 years old, general practitioner, Chelyabinsk
Effective drug for the treatment of hypertension in the second and third stages. I prescribe to patients as the main drug, when losartan alone is not enough to reduce pressure.
Alexander, 57 years old, Kazan
I have been taking this remedy for more than 10 years, as I suffer from hypertension. I used to take lisinopril, but a cough appeared that was not filmed in any way. The family doctor said that it was a side effect of lisinopril and transferred me to drugs from the group of angiotensin receptor inhibitors. Losartan makes it easier to control blood pressure numbers, and the cough has almost disappeared.
Dmitry, 68 years old, Astrakhan
I suffer from hypertension for over 20 years. Recently, doctors diagnosed heart failure. They said that this was due to decompensation of hypertension, and they prescribed this drug. I feel that my dyspnea has decreased a bit and my strength has increased a little more, which I am glad of.